Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD) significantly contribute to the 47 million people world-wide who suffer with dementia. This number is estimated to increase to over 130 million people by 2050.

Cognitive impairment and memory loss caused by decreased brain blood flow, decreased brain oxygenation and brain inflammation are serious problems often resulting from treatments for other medical conditions such as heart disease, major invasive surgery and vascular dementia.  In addition, scientific studies have linked early Alzheimer’s to inflammation in the brain. There are currently no effective treatments for inflammation related brain disease and memory loss.

ProNeurogen Therapeutics’ novel peptides inhibit this inflammatory cascade and improve brain blood flow. These peptides are designed to significantly improve serum half-life and penetrate the blood-brain-barrier. These peptides act to inhibit the inflammatory pathways at both the level of brain blood vessels and the brain itself.

 

 

CHRONIC NEUROPATHIC PAIN

 Approximately 100 million American adults suffer from chronic pain with an estimated societal cost of $600 billion annually.

Chronic pain continues to be an enormous unmet medical need with a far-reaching impact on society.

ProNeurogen’s Pain Drug Candidates

•Novel approach – new  peptide drug class

•Glycosylated-Ang-(1-7) Peptides

•Target: MasR receptor

•Mechanism: Anti-inflammatory

•Excellent Brain Penetration

•Efficacious for chronic bone pain, neuropathic pain

•Extremely safe