ProNeurogen Peptides are Selective Mas Receptor Agonists

•PNA5 is a glycosylated-Angiotensin-(1-7) peptide related to the Renin-Angiotensin family

•PNA5 binds to small GPCR Mas receptor

•PNA5 activation of Mas results in inhibition of inflammation, ROS and increased brain blood flow via activation of e-NOS.

•Through these mechanisms, PNA5 actions result in neuroprotection and improved memory function.